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The following serious adverse reactions were reported in postmarketing experience and are discussed in greater detail in other sections of the labeling:

  • Neuropsychiatric symptoms and suicidality
  • Angioedema and hypersensitivity reactions
  • Serious skin reactions
  • Accidental injury

    In the placebo-controlled studies, the most common adverse events associated with Chantix (Champix) (>5% and twice the rate seen in placebo-treated patients) were nausea, abnormal (vivid, unusual, or strange) dreams, constipation, flatulence, and vomiting.

    The treatment discontinuation rate due to adverse events in patients dosed with 1 mg twice daily was 12% for Chantix (Varenicline Tartrate), compared to 10% for placebo in studies of three months' treatment. In this group, the discontinuation rates that are higher than placebo for the most common adverse events in Chantix-treated patients were as follows: nausea (3% vs. 0.5% for placebo), insomnia (1.2% vs. 1.1% for placebo), and abnormal dreams (0.3% vs. 0.2% for placebo).

    Smoking cessation, with or without treatment, is associated with nicotine withdrawal symptoms and has also been associated with the exacerbation of underlying psychiatric illness.

    Clinical Trials Experience

    Because clinical trials are conducted under widely varying conditions, the adverse reactions rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

    During the premarketing development of Varenicline (Chantix), over 4500 subjects were exposed to this medicine, with over 450 treated for at least 24 weeks and approximately 100 for a year. Most study participants were treated for 12 weeks or less.

    The most common adverse event associated with Varenicline Tartrate (Chantix) treatment is nausea, occurring in 30% of patients treated at the recommended dose, compared with 10% in patients taking a comparable placebo regimen.

    MedDRA High Level Group Terms (HLGT) reported in >= 5% of patients in the Chantix 1 mg twice daily dose group, and more commonly than in the placebo group, are listed, along with subordinate Preferred Terms (PT) reported in >= 1% of Chantix (Varenicline) patients (and at least 0.5% more frequent than placebo). Closely related Preferred Terms such as "Insomnia", "Initial insomnia", "Middle insomnia", "Early morning awakening" were grouped, but individual patients reporting two or more grouped events are only counted once.

    Following is a list of treatment-emergent adverse events reported by patients treated with Chantix (Champix) during all clinical trials. The listing does not include those events already listed in the previous tables or elsewhere in labeling, those events for which a drug cause was remote, those events which were so general as to be uninformative, and those events reported only once which did not have a substantial probability of being acutely life-threatening.

    Blood and Lymphatic System Disorders

    Infrequent: anemia

    Cardiac Disorders

    Infrequent: arrhythmia, angina pectoris, bradycardia, myocardial infarction, tachycardia, palpitations, ventricular extrasystoles. Rare: atrial fibrillation, cardiac flutter, acute coronary syndrome, cor pulmonale, coronary artery disease.

    Ear and Labyrinth Disorders

    Infrequent: vertigo, tinnitus. Rare: deafness, Meniere's disease.

    Endocrine Disorders

    Infrequent: thyroid gland disorders.

    Eye Disorders

    Infrequent: dry eye, eye irritation, conjunctivitis, eye pain, visual disturbance, vision blurred. Rare: blindness transient, acquired night blindness, cataract subcapsular, photophobia, ocular vascular disorder, vitreous floaters.

    Gastrointestinal Disorders

    Frequent: diarrhea. Infrequent: enterocolitis, dysphagia, eructation, gastritis, esophagitis, gastrointestinal hemorrhage, mouth ulceration. Rare: intestinal obstruction, gastric ulcer, pancreatitis acute.

    General Disorders and Administration Site Conditions

    Frequent: edema, chest pain, influenza-like illness. Infrequent: chills, chest discomfort, pyrexia.

    Hepatobiliary Disorders

    Infrequent: gall bladder disorder.


    Frequent: liver function test abnormal, weight increased. Infrequent: muscle enzyme increased, electrocardiogram abnormal, urine analysis abnormal.

    Metabolism and Nutrition Disorders

    Infrequent: diabetes mellitus, hyperlipidemia, hypokalemia. Rare: hypoglycemia.

    Musculoskeletal and Connective Tissue Disorders

    Frequent: back pain, arthralgia, muscle cramp, musculoskeletal pain, myalgia. Infrequent: arthritis, osteoporosis. Rare: myositis.

    Nervous System Disorders

    Frequent: dizziness, disturbance in attention, sensory disturbance. Infrequent: migraine, parosmia, amnesia, psychomotor hyperactivity, syncope, restless legs syndrome, tremor. Rare: cerebrovascular accident, balance disorder, convulsion, dysarthria, mental impairment, facial palsy, multiple sclerosis, psychomotor skills impaired, nystagmus, transient ischemic attack, visual field defect.

    Psychiatric Disorders

    Infrequent: dissociation, disorientation, libido decreased, thinking abnormal, mood swings. Rare: bradyphrenia, euphoric mood.

    Renal and Urinary Disorders

    Frequent: polyuria. Infrequent: nocturia, nephrolithiasis, urethral syndrome, urine abnormality. Rare: renal failure acute, urinary retention.

    Reproductive System and Breast Disorders

    Rare: sexual dysfunction. Frequent: menstrual disorder. Infrequent: erectile dysfunction.

    Respiratory, Thoracic and Mediastinal Disorders

    Frequent: respiratory disorders, epistaxis. Infrequent: asthma. Rare: pleurisy, pulmonary embolism.

    Skin and Subcutaneous Tissue Disorders

    Frequent: hyperhidrosis. Infrequent: dry skin, acne, eczema, psoriasis, erythema, urticaria. Rare: photosensitivity reaction.

    Vascular Disorders

    Frequent: hot flush. Infrequent: thrombosis.

    Chantix (Varenicline Tartrate) has also been studied in a trial conducted in patients with stable cardiovascular disease, a trial conducted in patients with chronic obstructive pulmonary disease (COPD) and a trial conducted in generally healthy patients (similar to those in the premarketing studies) in which they were allowed to select a quit date between days 8 and 35 of treatment (alternative quit date instruction trial).

    In the trial of patients with stable cardiovascular disease, more types and a greater number of cardiovascular events were reported compared to premarketing studies. Treatment-emergent (on-treatment or 30 days after treatment) cardiovascular events reported with a frequency >= 1% in either treatment group in this study were angina pectoris (3.7% and 2.0% for varenicline and placebo, respectively), chest pain (2.5% vs. 2.3%), peripheral edema (2.0% vs. 1.1%), hypertension (1.4% vs. 2.6%), and palpitations (0.6 % vs. 1.1%). Deaths and serious cardiovascular events occurring over the 52 weeks of the study (treatment emergent and non-treatment emergent) were adjudicated by a blinded, independent committee. The following treatment-emergent adjudicated events occurred with a frequency >1% in either treatment group: nonfatal MI (1.1% vs. 0.3% for varenicline and placebo, respectively), and hospitalization for angina pectoris (0.6% vs. 1.1%). During non-treatment follow up to 52 weeks, the adjudicated events included need for coronary revascularization (2.0% vs. 0.6%), hospitalization for angina pectoris (1.7% vs. 1.1%), and new diagnosis of peripheral vascular disease (PVD) or admission for a PVD procedure (1.1% vs. 0.6%). Some of the patients requiring coronary revascularization underwent the procedure as part of management of nonfatal MI and hospitalization for angina. Cardiovascular death occurred in 0.3% of patients in the varenicline arm and 0.6% of patients in the placebo arm over the course of the 52-week study.

    Adverse events in the trial of patients with COPD and in the alternative quit date instruction trial were quantitatively and qualitatively similar to those observed in premarketing studies.

    Postmarketing Experience

    The following adverse events have been reported during post-approval use of Varenicline (Chantix). Because these events are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

    There have been reports of mania, depression, psychosis, paranoia, hallucinations, delusions, aggression, homicidal ideation, hostility, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide in patients attempting to quit smoking while taking Varenicline Tartrate (Chantix). Smoking cessation with or without treatment is associated with nicotine withdrawal symptoms and the exacerbation of underlying psychiatric illness. Not all patients had known pre-existing psychiatric illness and not all had discontinued smoking.

    There have been reports of hypersensitivity reactions, including angioedema.

    There have also been reports of serious skin reactions, including Stevens-Johnson Syndrome and erythema multiforme, in patients taking this medication.

    There have been reports of myocardial infarction (MI) and cerebrovascular accident (CVA) including ischemic and hemorrhagic events in patients taking Chantix. In the majority of the reported cases, patients had preexisting cardiovascular disease and/or other risk factors. Although smoking is a risk factor for MI and CVA, based on temporal relationship between medication use and events, a contributory role of varenicline cannot be ruled out.

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