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CHANTIX (CHAMPIX): DOSAGE AND ADMINISTRATION
Usual Dosage for Adults
Smoking cessation therapies are more likely to succeed for patients who are motivated to stop smoking and who are provided additional advice and support. Provide patients with appropriate educational materials and counseling to support the quit attempt.
The patient should set a date to stop smoking. Begin Chantix (Varenicline) dosing one week before this date. Alternatively, the patient can begin this medication dosing and then quit smoking between days 8 and 35 of treatment.
Chantix should be taken after eating and with a full glass of water.
The recommended dose of this drug is 1 mg twice daily following a 1 week titration as follows:
Days 1 – 3: 0.5 mg once daily
Days 4 – 7: 0.5 mg twice daily
Day 8 – end of treatment: 1 mg twice daily
Patients should be treated with Chantix (Varenicline Tartrate) for 12 weeks. For patients who have successfully stopped smoking at the end of 12 weeks, an additional course of 12 weeks' treatment with this medicine is recommended to further increase the likelihood of long-term abstinence.
Patients who do not succeed in stopping smoking during 12 weeks of initial therapy, or who relapse after treatment, should be encouraged to make another attempt once factors contributing to the failed attempt have been identified and addressed.
Consider a temporary or permanent dose reduction in patients who cannot tolerate the adverse effects of Chantix (Champix).
Dosage in Special Populations
Patients with Impaired Renal Function: No dosage adjustment is necessary for patients with mild to moderate renal impairment. For patients with severe renal impairment (estimated creatinine clearance < 30 mL / min), the recommended starting dose of Varenicline (Chantix) is 0.5 mg once daily. The dose may then be titrated as needed to a maximum dose of 0.5 mg twice a day. For patients with end-stage renal disease undergoing hemodialysis, a maximum dose of 0.5 mg once daily may be administered if tolerated.
Elderly and Patients with Impaired Hepatic Function: No dosage adjustment is necessary for patients with hepatic impairment. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
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Chantix (Champix) prescribing information
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